Assessment of Urinary Podocin Level as an Early Indicator in Diabetic Nephropathy
نویسندگان
چکیده
منابع مشابه
Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy
Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM). Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis. Towards this aim, biomarkers for detecting early DN can be used. Microalbuminuria has been proven a remarkably useful biomarker, being used for diagnosis of DN, for assessing its associated condition-mainly cardiov...
متن کاملAssessment of Urinary Osteopontin in Association with Podocyte for Early Predication of Nephropathy in Diabetic Patients
OBJECTIVES Microalbuminuria has been clinically used for noninvasive evaluation of renal dysfunctions. However, it is a nonspecific marker of diabetic nephropathy (DN). METHODS This study was conducted from March 2012 to April 2013 at Biochemistry Unit, King Fahd Medical Research Center (KFMRC). In this study, urinary osteopontin, podocytes number, and levels of immunoglobulin M (IgM) were de...
متن کاملUrinary Markers of Tubular Injury in Early Diabetic Nephropathy
Diabetic nephropathy (DN) is a common and serious complication of diabetes associated with adverse outcomes of renal failure, cardiovascular disease, and premature mortality. Early and accurate identification of DN is therefore of critical importance to improve patient outcomes. Albuminuria, a marker of glomerular involvement in early renal damage, cannot always detect early DN. Thus, more sens...
متن کاملUrinary Proteomics for Early Diagnosis in Diabetic Nephropathy
Diabetic nephropathy (DN) is a progressive kidney disease, a well-known complication of long-standing diabetes. DN is the most frequent reason for dialysis in many Western countries. Early detection may enable development of specific drugs and early initiation of therapy, thereby postponing/preventing the need for renal replacement therapy. We evaluated urinary proteome analysis as a tool for p...
متن کاملEarly urinary and plasma biomarkers for experimental diabetic nephropathy.
BACKGROUND As the prevalence of diabetes rises, its complications such as diabetic nephropathy affect an increaseing number of patients. Consequently, the need for biomarkers in rodent models which reflect the stage and course of diabetic nephropathy is high. This article focuses on Heart-type fatty acid binding protein (H-FABP), osteopontin (OPN), nephrin, and Neutrophil gelatinase-associated ...
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ژورنال
عنوان ژورنال: Zagazig University Medical Journal
سال: 2019
ISSN: 2357-0717
DOI: 10.21608/zumj.2019.10380.10960